Krish Biotech Research Pvt. Ltd. (KBRPL) conducts studies on Agrochemicals that compromises of Pesticides and Biocides in accordance with the various international guidelines like OECD, OCSPP, EEC, ISO, CIB & RC and JMAFF. We also conduct studies on Biocides which are active substances and preparations containing one or more active substances, put up in the form in which they are supplied to the user, intended to destroy, deter, render harmless, prevent the action of, or otherwise exert a controlling effect on any harmful organism by chemical or biological means. We have expertise on conducting various studies required for Chemistry and Toxicology.

Krish Biotech Research Pvt. Ltd. (KBRPL) the changing times, there has been constant evolution in the drug development, market dynamics, nature and demand of drugs. We ensure that we at KBRPL offer the best solutions which are reliable and quality tested. KBRPL supports drug discovery program by conducting preclinical safety assessment toxicology studies. Don’t let your drug candidate lack in terms of safety assessment. We are having expertise in conducting safety and assessment studies in line with ICH, FDA Redbook, WHO, EMEA and Schedule Y. We extend our proficiency on to dose formulation analysis, bioanalytical chemistry sample assays for drug concentration, pathology and peer review services, specialized statistical analyses and to determine toxico-kinetic and pharmacokinetics. Routes of Administration: Dermal, intranasal, Intravaginal and intra-penile, Ocular. Oral (gavage, diet and capsule). Parenteral (intravenous, subcutaneous, intradermal, intramuscular and intraperitoneal) and Rectal. Our scientific experts have the capability for the additional parameters required at
pre¬clinical stage in like:
• Single dose studies
• Repeated dose studies
• Chronic Toxicity Studies
• DART Studies
• Immuno-toxicity studies
• Analytical Capabilities (like pre-formulation studies, API method development and validation, Bioanalytical method development and method validation).

Krish Biotech Research Pvt. Ltd. (KBRPL) The medical device industry is vast and newly developing each day, offering vast range of products each serving their varied functions. Advancement in fields of technology have prompted the need for the validation of these devices. Toxicological evaluation of the medical device is imperative for the establishment of safety in humans. We offer varied range of testing namely Cytotoxicity, sensitization namely Local Lymph Node Assay (LLNA), Contact Hypersensitivity (GPMT), Pyrogenicity, Geno toxicity, Carcinogenicity and Reproductive Toxicity among others.

Krish Biotech Research Pvt. Ltd. (KBRPL) These are used for therapeutic and prophylactic purposes in order to regulate infections of bacterial nature and prevent the outbreak of animal diseases. We work with several veterinary drugs which are beneficial for animal health and development.

Krish Biotech Research Pvt. Ltd. (KBRPL) REACH (Registration, Evaluation and Authorization of Chemicals) is an EC 1907/2006 Regulation, which came into force on 1st June 2007 and replaces all previous legislation on authorization of chemicals in the countries of European Union (EU).
This regulation is for all the type of chemicals that are either manufactured in or imported into the EU in quantities greater than 1 ton/year. According to REACH requirements, an industry has the responsibility to ensure that the manufactured and imported chemicals that are under trade in EU countries do not adversely affect human health or the environment. It requires manufacturers and importers of chemicals into the European Union (EU) to submit probable hazard and risk data for all substances. We have expertise in generation of toxicity data in following aspects:
Acute toxicity studies: Assess the short-term effects of the test compound on general biological functions. At KBRPL we conduct preclinical studies with rodents and non-rodents. We have expertise over wide spectrum of studies like acute (Oral, Dermal, Inhalation, Dermal irritation, Mucous Membrane Irritation, Skin Sensitization by either Magnusson & Kligman Method, Buehler Method or Local Lymph Node Assay (LLNA)) and Sub-chronic by various routes of administration (Chronic, Developmental and Reproductive Toxicity, in vitro and in vivo Mutagenicity. These studies are performed in compliance with global regulatory guidelines, viz.EEC, OECD, OPPTS, JMAFF and TSCA.
Chemistry Studies: Conducting Physico-chemical studies for technical grade and formulation compounds
Ecotoxicology Studies
• Acute toxicity test in fish
• Acute toxicity test in daphnia
• Acute toxicity test in alga
• Acute toxicity test in earthworms
• Acute toxicity test in silkworms
• Acute toxicity test in honey bee (oral & contact)
• Acute Toxicity in birds
• Avian Dietary Toxicity in birds

Krish Biotech Research Pvt. Ltd. (KBRPL) In the current scenario, natural products and their derivatives represent more than 50% of all the drugs in modern age as well as Nutraceuticals (mixture of Nutrition and pharmaceutical). Research and development of conventional drugs are very expensive thus researchers have focused on the discovery from herbal medicines or botanical sources. We also conduct toxicology studies required for the registration of herbal & Nutraceuticalsin various regulatory authorities like EMA, WHO, FDA etc. Our expertise includes:
• Acute toxicity tests using at least two species one of them being a non-rodent.
• Subacute toxicity tests
• Chronic toxicity tests
• Mutagenic tests using salmonella (Ames test) or other tests
• Teratogenicity tests if a product is to be administered to pregnant women
• Immuno-toxicity (test for allergic reactions)
• Reproductive toxicity tests
• Active ingredient method development and analysis
We at KBRPL take care of your preclinical toxicity data generation in accordance with the regulatory needs.